Host immune competence and local ischemia affects the functionality of engineered vasculature.

@article{Chen2007HostIC,
  title={Host immune competence and local ischemia affects the functionality of engineered vasculature.},
  author={Ruth Ruoying Chen and Jonathan K Snow and Jack P Palmer and Angela Sheue-Ping Lin and Craig L Duvall and Robert Erling Guldberg and David J Mooney},
  journal={Microcirculation},
  year={2007},
  volume={14 2},
  pages={
          77-88
        }
}
OBJECTIVE Localized and sustained delivery of vascular endothelial growth factor (VEGF) is a promising approach to overcome the limited efficacy of bolus delivery. The authors examined the effects of host immune competence and local ischemia on the functionality of new vessel networks formed with this approach. METHODS Vessel structure and perfusion resulting from implantation of porous 85:15 poly(lactide-co-glycolide) scaffolds releasing VEGF165 were measured in both subcutaneous tissue and… CONTINUE READING
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