Host genetics and infectious disease.

  title={Host genetics and infectious disease.},
  author={David J. Weatherall},
  volume={112 Suppl},
Recent work on the inheritance of susceptibility of malaria suggests that, over what may have been a relatively short evolutionary period, a remarkably diverse series of gene families have been modified in response to the selective drive of this single infection. The phenotype consequences are not confined to the red cell, but involve the immune system, cytokines and many other systems. It seems likely that the mechanisms of variation in genetic susceptibility to other infective agents will… CONTINUE READING