Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication.

@article{Cristea2010HostFA,
  title={Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication.},
  author={Ileana M. Cristea and Heather M. Rozjabek and Kelly L. Rulison Molloy and Sophiya Karki and Laura L White and Charles M. Rice and Michael P. Rout and Brian T Chait and Margaret R Macdonald},
  journal={Journal of virology},
  year={2010},
  volume={84 13},
  pages={6720-32}
}
Sindbis virus (SINV) is the prototype member of the Alphavirus genus, whose members cause severe human diseases for which there is no specific treatment. To ascertain host factors important in the replication of the SINV RNA genome, we generated a SINV expressing nsP4, the viral RNA-dependent RNA polymerase, with an in-frame 3xFlag epitope tag. Proteomic analysis of nsP4-containing complexes isolated from cells infected with the tagged virus revealed 29 associated host proteins. Of these, 10… CONTINUE READING
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SINDBIS VIRUS nsP4 INTERACTING HOST FACTORS

  • H. Tourriere, K. Chebli, L. Zekri, B. Courselaud, J. M. Blanchard, E. VOL
  • J. Cell Biol
  • 2010
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