Host factor Ebp1: selective inhibitor of influenza virus transcriptase.

  title={Host factor Ebp1: selective inhibitor of influenza virus transcriptase.},
  author={Ayae Honda and Takuto Okamoto and Akira Ishihama},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={12 2},
Influenza virus RNA polymerase is composed of three virus-coded proteins, and is involved in both transcription and replication of the negative-strand genome RNA. Subunit PB1 plays key roles in both the RNA polymerase assembly and the catalytic function of RNA polymerization. Using yeast two-hybrid screening, a HeLa cell protein with the molecular mass of 45 kDa was identified. After cloning and sequencing, this protein was identified to be Ebp1, ErbB3-binding protein. Epb1 specifically… CONTINUE READING
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