Host determinants of HIV-1 control in African Americans.

  title={Host determinants of HIV-1 control in African Americans.},
  author={Kimberly Elise Pelak and David K. Goldstein and Nicole M. Walley and Jacques Fellay and Dongliang Ge and Kevin V. Shianna and Curtis Gumbs and Xiaojiang Gao and Jessica M. Maia and Kenneth D. Cronin and Shehnaz K. Hussain and Mary N Carrington and Nelson L Michael and Amy C. Weintrob},
  journal={The Journal of infectious diseases},
  volume={201 8},
We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses… CONTINUE READING
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