Host defense peptides and lipopeptides: modes of action and potential candidates for the treatment of bacterial and fungal infections.

@article{Shai2006HostDP,
  title={Host defense peptides and lipopeptides: modes of action and potential candidates for the treatment of bacterial and fungal infections.},
  author={Yechiel Shai and Arik Makovitzky and Dorit Avrahami},
  journal={Current protein & peptide science},
  year={2006},
  volume={7 6},
  pages={
          479-86
        }
}
Endogenous peptide antibiotics (termed also host-defense or antimicrobial peptides) are known as evolutionarily old components of innate immunity. They were found initially in invertebrates, but later on also in vertebrates, including humans. This secondary, chemical immune system provides organisms with a repertoire of small peptides that act against invasion (for both offensive and defensive purposes) by occasional and obligate pathogens. Each antimicrobial peptide has a broad but not… CONTINUE READING
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