Host defense mechanisms in secondary syphilitic lesions: a role for IFN-gamma-/IL-17-producing CD8+ T cells?

@article{Stary2010HostDM,
  title={Host defense mechanisms in secondary syphilitic lesions: a role for IFN-gamma-/IL-17-producing CD8+ T cells?},
  author={Georg Stary and Irene Klein and Marie-Charlotte Br{\"u}ggen and Sabine Kohlhofer and P M Brunner and Daniel Spazierer and Leonhard M{\"u}llauer and Peter Petzelbauer and Georg Stingl},
  journal={The American journal of pathology},
  year={2010},
  volume={177 5},
  pages={2421-32}
}
Cell-mediated immunity is thought to be of critical importance in antisyphilitic host defense, but the exact mechanisms are still unknown. This fact is particularly true for HIV-infected persons with a deficit in CD4+ T-cell number. We therefore obtained lesional skin samples from HIV+ and HIV- patients with secondary syphilis at different time points of lesional age to search both for causative microorganisms and to characterize the inflammatory infiltrate. By doing so, we detected Treponema… CONTINUE READING

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