Host defense effector molecules in mucosal secretions.


Mucosal secretions contain a range of defense effector molecules including antimicrobial peptides and proteinase inhibitors. These molecules play a central role in host defense against infection, and in a variety of immune and inflammatory reactions. The aim of this study was to analyze the levels of neutrophil defensins, the cathelicidin hCAP-18/LL-37, and the proteinase inhibitors secretory leukocyte proteinase inhibitor, SKALP/elafin and cystatin M/E in various mucosal secretions and urine. We show here that especially seminal plasma is characterized by high concentrations of hCAP-18/LL-37, SLPI, SKALP/elafin and cystatin M/E. The results of this study demonstrate that each mucosal secretion is characterized by a unique profile of effector molecules, which may supply individual mucosal secretions with specific properties related to the control of local infection and inflammation.

Cite this paper

@article{Tjabringa2005HostDE, title={Host defense effector molecules in mucosal secretions.}, author={Geuranne S. Tjabringa and J. B. Vos and Diana Olthuis and Dennis K. Ninaber and Klaus Friedrich Rabe and Joost Schalkwijk and Pieter S Hiemstra and Patrick L. J. M. Zeeuwen}, journal={FEMS immunology and medical microbiology}, year={2005}, volume={45 2}, pages={151-8} }