Host defense antimicrobial peptides as antibiotics: design and application strategies.

  title={Host defense antimicrobial peptides as antibiotics: design and application strategies.},
  author={Biswajit Mishra and Scott A Reiling and D Zarena and Guangshun Wang},
  journal={Current opinion in chemical biology},
This review deals with the design and application strategies of new antibiotics based on naturally occurring antimicrobial peptides (AMPs). The initial candidate can be designed based on three-dimensional structure or selected from a library of peptides from natural or laboratory sources followed by optimization via structure-activity relationship studies. There are also advanced application strategies such as induction of AMP expression from host cells by various factors (e.g., metals, amino… CONTINUE READING
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