Host defense against Mycobacterium avium does not have an absolute requirement for major histocompatibility complex class I-restricted T cells.

@article{Bermudez1999HostDA,
  title={Host defense against Mycobacterium avium does not have an absolute requirement for major histocompatibility complex class I-restricted T cells.},
  author={Luiz E. Bermudez and Mary Petrofsky},
  journal={Infection and immunity},
  year={1999},
  volume={67 6},
  pages={3108-11}
}
The role of CD8(+) T cells was evaluated in a mouse model of disseminated Mycobacterium avium infection. C57BL/6J and C57BL/6Jbeta2-/- (beta2-/-) mice were infected intravenously, and the number of viable bacteria in each liver and spleen was determined. No significant difference between the number of bacteria in the two strains of mice was observed at 2, 4, 6, and 8 weeks after infection. Histopathological examination of granulomas from C57BL/6J and beta2-/- mice did not show any difference… CONTINUE READING

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