Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome.

@article{Sun2012HostCS,
  title={Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome.},
  author={Yulan Sun and Cong Jin and Faxian Zhan and Xianjun Wang and Mifang Liang and Quan-fu Zhang and Shu-jun Ding and Xu-hua Guan and Xi-xiang Huo and Chuan Li and Jing Qu and Qin Wang and Shuo Zhang and Yanping Zhang and Shiwen Wang and Anqiang Xu and Zhenqiang Bi and De-xin Li},
  journal={The Journal of infectious diseases},
  year={2012},
  volume={206 7},
  pages={
          1085-94
        }
}
BACKGROUND Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease in China, caused by SFTS virus (SFTSV). Severe SFTS patients can quickly proceed to multiorgan dysfunction and death; however, underlying pathogenic mechanisms remain unclear. METHODS Serum samples from 15 fatal and 44 nonfatal SFTS cases were subjected to multiplex-microbead immunoassays to detect a broad spectrum of cytokines. The viral load and virus-specific IgG titers were also tested by real-time… 
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Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome
TLDR
The concentration of IFN-α as well as other cytokines (IFN-γ, G-CSF, MIP-1α, IL-6, and IP-10) is correlated with the severity of SFTS, suggesting that type I interferon may not be significant in resistance SFTSV infection in humans and it may play an import role in cytokine storm.
Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome
Downregulation of Interferon-β and Inhibition of TLR3 Expression are associated with Fatal Outcome of Severe Fever with Thrombocytopenia Syndrome
TLDR
It is found that high level viremia, reduced platelets, coagulation dysfunction, multi-organ injuries, elevated IL-6 and TNF-α were closely associated with the aggravation of SFTS.
Changes in peripheral blood cytokines in patients with severe fever with thrombocytopenia syndrome
TLDR
Investigation of the pathogenic mechanism of severe fever with thrombocytopenia syndrome found SFTSV could cause a cytokine change: the cytokine levels of patients had different degrees of fluctuation after the onset of the disease, and the levels of IL‐6, IP‐10, and RANTES were correlated with the viral load.
The Regulation of Seventeen Inflammatory Mediators are Associated with Patient Outcomes in Severe Fever with Thrombocytopenia Syndrome
TLDR
It was demonstrated that dysregulated inflammatory response was associated with disease pathogenesis and mortality in SFTS patients and the concentrations of RANTES and PDGF were remarkably positively correlated with the platelet count.
Viral and Immunologic Factors Associated with Fatal Outcome of Patients with Severe Fever with Thrombocytopenia Syndrome in Korea
TLDR
Investigation of virologic and immunologic factors for fatal outcomes of patients with SFTS found severe signs of inflammation such as a high plasma concentration of IFN-α, IL-10, IP- 10,IFN-γ, IL,6,IL-8, MCP-1, MIP-1α, and G-CSF, and inadequate antibody response during the disease course were associated with mortality in SFTS patients.
Pathology of Severe Fever with Thrombocytopenia Syndrome
  • M. Saijo
  • Medicine
    Severe Fever with Thrombocytopenia Syndrome
  • 2019
TLDR
The mechanisms behind the high CFR may be multi-organ failure induced by hemophagocytic syndrome and coagulopathy due to disseminated intravascular coagulation causing bleeding tendency, and understanding of the pathophysiology of SFTS is required to reduce the morbidity and mortality.
Pathophysiology of severe fever with thrombocytopenia syndrome and development of specific antiviral therapy.
  • M. Saijo
  • Medicine
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
  • 2018
Molecular Signatures of Inflammatory Profile and B-Cell Function in Patients with Severe Fever with Thrombocytopenia Syndrome
TLDR
It is demonstrated that SFTSV infection in fatal cases caused an excessive inflammatory response through high induction of proinflammatory cytokines and chemokines and the aberrant inactivation of adaptive immune responses.
Decreased myeloid dendritic cells indicate a poor prognosis in patients with severe fever with thrombocytopenia syndrome.
  • Wenjing Zhang, Mengmeng Li, +7 authors Xin Zheng
  • Medicine, Biology
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • 2017
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