Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production.

@article{Bfica2005HostCO,
  title={Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production.},
  author={Andr{\'e} B{\'a}fica and Charles A Scanga and Charles N Serhan and Fabiana Sim{\~a}o Machado and Sandy L. White and Alan Sher and J{\'u}lio C. S. Aliberti},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 6},
  pages={1601-6}
}
Th1 type cytokine responses are critical in the control of Mycobacterium tuberculosis infection. Recent findings indicate that 5-lipoxygenase-dependent (5-LO-dependent) lipoxins regulate host IL-12 production in vivo. Here, we establish lipoxins as key chemical mediators in resistance to M. tuberculosis infection. High levels of lipoxin A4 (LXA4) were detected in sera from infected WT but not infected 5-LO-deficient mice. Moreover, lungs from M. tuberculosis-infected 5-lo-/- animals showed… CONTINUE READING

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