Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages.

@article{Nishikawa2011HostCS,
  title={Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages.},
  author={Yoshifumi Nishikawa and Hany Mohamed Ibrahim and Kyohko Kameyama and Ikumi Shiga and Jun Hiasa and Xuenan Xuan},
  journal={The Journal of veterinary medical science},
  year={2011},
  volume={73 5},
  pages={633-9}
}
The intracellular protozoan Toxoplasma gondii lacks the ability to synthesize sterol and scavenges cholesterol from the low-density lipoprotein receptor (LDLR) pathway of its host to facilitate replication. Sterol biosynthesis inhibitors, however, have a demonstrated anti-Toxoplasma effect. In this study, we examined the host mevalonate pathway as a novel source of cholesterol for T. gondii and its effects on parasite growth in macrophages. Parasite growth did not significantly change in the… CONTINUE READING

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