Host cell selection of influenza neuraminidase variants: implications for drug resistance monitoring in A(H1N1) viruses.

@article{OkomoAdhiambo2010HostCS,
  title={Host cell selection of influenza neuraminidase variants: implications for drug resistance monitoring in A(H1N1) viruses.},
  author={Margaret Okomo-Adhiambo and Ha Thi Thuy Nguyen and Katrina Sleeman and Tiffany G. Sheu and Varough M. Deyde and Rebecca Garten and Xiyan Xu and Michael W. Shaw and Alexander I. Klimov and Larisa V. Gubareva},
  journal={Antiviral research},
  year={2010},
  volume={85 2},
  pages={381-8}
}
The neuraminidase inhibitors (NAIs), oseltamivir and zanamivir, are essential for treatment and prevention of influenza A and B infections. Oseltamivir resistance among influenza A (H1N1) viruses rapidly emerged and spread globally during the 2007-2008 and 2008-2009 influenza seasons. Approximately 20% and 90% of viruses tested for NAI susceptibility at CDC during these seasons, respectively, were resistant to oseltamivir (IC(50) approximately 100-3000 time>those of sensitive viruses), based on… CONTINUE READING

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