Host cell proteins in biologics development: Identification, quantitation and risk assessment

  title={Host cell proteins in biologics development: Identification, quantitation and risk assessment},
  author={X. Wang and A. Hunter and N. Mozier},
  journal={Biotechnology and Bioengineering},
  • X. Wang, A. Hunter, N. Mozier
  • Published 2009
  • Biology, Medicine
  • Biotechnology and Bioengineering
  • Host cell proteins (HCPs) are those produced or encoded by the organisms and unrelated to the intended recombinant product. Some are necessary for growth, survival, and normal cellular processing whereas others may be non‐essential, simply carried along as baggage. Like the recombinant product, HCPs may also be modified by the host with a number of post‐translational modifications. Regardless of the utility, or lack thereof, HCPs are undesirable in the final drug substance. Though commonly… CONTINUE READING
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