Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma.

@article{Nishikawa2005HostCL,
  title={Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma.},
  author={Yoshifumi Nishikawa and Friederike Quittnat and Timothy T Stedman and Dennis R. Voelker and Jae-Yeon Choi and Matt Zahn and Mei Yang and Marc Pypaert and Keith A. Joiner and Isabelle Coppens},
  journal={Cellular microbiology},
  year={2005},
  volume={7 6},
  pages={849-67}
}
The intracellular protozoan Toxoplasma gondii lacks a de novo mechanism for cholesterol synthesis and therefore must scavenge this essential lipid from the host environment. In this study, we demonstrated that T. gondii diverts cholesterol from low-density lipoproteins for cholesteryl ester synthesis and storage in lipid bodies. We identified and characterized two isoforms of acyl-CoA:cholesterol acyltransferase (ACAT)-related enzymes, designated TgACAT1alpha and TgACAT1beta in T. gondii. Both… CONTINUE READING