Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.

@article{Tonkin2011HostCI,
  title={Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.},
  author={Michelle L. Tonkin and Magali Roques and Mauld H Lamarque and Martine Pugni{\`e}re and Dominique Douguet and Joanna Crawford and Maryse Lebrun and Martin J. Boulanger},
  journal={Science},
  year={2011},
  volume={333 6041},
  pages={463-7}
}
Apicomplexan parasites such as Toxoplasma gondii and Plasmodium species actively invade host cells through a moving junction (MJ) complex assembled at the parasite-host cell interface. MJ assembly is initiated by injection of parasite rhoptry neck proteins (RONs) into the host cell, where RON2 spans the membrane and functions as a receptor for apical membrane antigen 1 (AMA1) on the parasite. We have determined the structure of TgAMA1 complexed with a RON2 peptide at 1.95 angstrom resolution. A… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 11 times over the past 90 days. VIEW TWEETS
63 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

References

Publications referenced by this paper.

Chem

  • J. Crawford, M. L. Tonkin, O. Grujic, M. J. Boulanger, J. Biol
  • 285,
  • 1564
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…