Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete.

@article{Lin2015HostCH,
  title={Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete.},
  author={Yi-Pin Lin and Rudra Bhowmick and Jenifer Coburn and John M Leong},
  journal={Cellular microbiology},
  year={2015},
  volume={17 10},
  pages={
          1464-76
        }
}
Borrelia burgdorferi, the agent of Lyme disease, spreads from the site of the tick bite to tissues such as heart, joints and the nervous tissues. Host glycosaminoglycans, highly modified repeating disaccharides that are present on cell surfaces and in extracellular matrix, are common targets of microbial pathogens during tissue colonization. While several dermatan sulfate-binding B. burgdorferi adhesins have been identified, B. burgdorferi adhesins documented to promote spirochetal binding to… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 3 times. VIEW TWEETS

References

Publications referenced by this paper.
SHOWING 1-10 OF 65 REFERENCES

Similar Papers

Loading similar papers…