Host-cell cyclophilin is important for the intracellular replication of Leishmania major.

@article{Hoerauf1997HostcellCI,
  title={Host-cell cyclophilin is important for the intracellular replication of Leishmania major.},
  author={Achim Hoerauf and Christine Rascher and Renate Bang and Andreas Pahl and W Solbach and Kay Brune and Martin Roellinghoff and Haejeen Bang},
  journal={Molecular microbiology},
  year={1997},
  volume={24 2},
  pages={421-9}
}
The antiparasitic effects of cyclosporin A were examined in leishmanial infection by analysing the role of CsA-binding proteins (cyclophilins) in the host-parasite interaction. We hypothesized that the leishmanicidal effects of CsA on Leishmania major infected macrophages might be mediated through a cyclophilin of either the parasite or the host cell. Two cyclophilins (20 and 22 kDa) were purified from L. major parasites and N-terminally sequenced. Although enzyme activity of these cyclophilins… CONTINUE READING

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