Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action.

@article{Kim2012HostCA,
  title={Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action.},
  author={J Kim and H J Lee and Dong-Min Shin and Wonho Kim and Jae Min Yuk and Hyo Sun Jin and Sang-Hee Lee and Guang-Ho Cha and Jin-Man Kim and Z N Lee and Sung Jae Shin and Heekyung Yoo and Young Kil Park and Jin Bong Park and Jongkyeong Chung and Tamotsu Yoshimori and Eun Kyeong Jo},
  journal={Cell host & microbe},
  year={2012},
  volume={11 5},
  pages={457-68}
}
The current standard of treatment against tuberculosis consists of a cocktail of first-line drugs, including isoniazid and pyrazinamide. Although these drugs are known to be bactericidal, contribution of host cell responses in the context of antimycobacterial chemotherapy, if any, remains unknown. We demonstrate that isoniazid and pyrazinamide promote autophagy activation and phagosomal maturation in Mycobacterium tuberculosis (Mtb)-infected host cells. Treatment of Mtb-infected macrophages… CONTINUE READING
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