Host cell and EBNA-2 regulation of Epstein-Barr virus latent-cycle promoter activity in B lymphocytes.

@article{Rooney1992HostCA,
  title={Host cell and EBNA-2 regulation of Epstein-Barr virus latent-cycle promoter activity in B lymphocytes.},
  author={Cliona M Rooney and Matthew Brimmell and M Buschle and Gordon Allan and Paul J. Farrell and John L. Kolman},
  journal={Journal of virology},
  year={1992},
  volume={66 1},
  pages={496-504}
}
The six latent-cycle nuclear antigens (EBNAs) of Epstein-Barr virus (EBV), whose genes share 5' leader exons and two promoters (Cp and Wp), are differentially expressed by cells of the B lineage. To examine the possibility that EBNA gene expression is regulated through selective use of Cp and Wp, we monitored the activity of promoter-chloramphenicol acetyltransferase (CAT) gene constructs transfected into EBV-positive and EBV-negative B lymphocytes and Burkitt's lymphoma cells. Wp was a much… CONTINUE READING
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