Host-bacterial interactions in the initiation of inflammation.

  title={Host-bacterial interactions in the initiation of inflammation.},
  author={Deepa Rastogi and Adam J Ratner and Alice Prince},
  journal={Paediatric respiratory reviews},
  volume={2 3},
The respiratory epithelium provides both a physical and an immunological barrier to inhaled pathogens. In the normal host, innate defences prevent bacteria from activating inflammation by providing efficient muco-ciliary clearance and antimicrobial activity. Bacteria that persist in the airway lumen, as in cystic fibrosis, activate both the professional immune cells in the respiratory mucosa as well as the more abundant airway epithelial cells. As most of the bacteria become entrapped in airway… CONTINUE READING


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