Host and viral determinants of Mx2 antiretroviral activity.

  title={Host and viral determinants of Mx2 antiretroviral activity.},
  author={Idoia Busnadiego and Melissa Kane and Suzannah J. Rihn and Hannah F Preugschas and Joseph Hughes and Daniel Blanco-Melo and Victoria P Strouvelle and Trinity M. Zang and Brian J. Willett and Chris Boutell and Paul D Bieniasz and Sam Wilson},
  journal={Journal of virology},
  volume={88 14},
Myxovirus resistance 2 (Mx2/MxB) has recently been uncovered as an effector of the anti-HIV-1 activity of type I interferons (IFNs) that inhibits HIV-1 at an early stage postinfection, after reverse transcription but prior to proviral integration into host DNA. The mechanistic details of Mx2 antiviral activity are not yet understood, but a few substitutions in the HIV-1 capsid have been shown to confer resistance to Mx2. Through a combination of in vitro evolution and unbiased mutagenesis, we… CONTINUE READING
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7750 Journal of Virology on D ecem er 24, 2017 by gest http/jvi.asm .rg/ D ow nladed fom Malim MH

  • C Goujon, T Schaller, +5 authors Busnadiego
  • Retrovirology
  • 2013
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