Host adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis.

@article{Pierce2009HostAA,
  title={Host adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis.},
  author={Deanne L. Pierce and So-ichiro Nishiyama and Shuang Liang and Min Wang and Martha Triantafilou and Kathy Triantafilou and Fuminobu Yoshimura and Donald R Demuth and George Hajishengallis},
  journal={Infection and immunity},
  year={2009},
  volume={77 8},
  pages={3294-301}
}
The fimbriae of Porphyromonas gingivalis mediate critical roles in host colonization and evasion of innate defenses and comprise polymerized fimbrilin (FimA) associated with quantitatively minor accessory proteins (FimCDE) of unknown function. We now show that P. gingivalis fimbriae lacking FimCDE fail to interact with the CXC-chemokine receptor 4 (CXCR4), and bacteria expressing FimCDE-deficient fimbriae cannot exploit CXCR4 in vivo for promoting their persistence, as the wild-type organism… CONTINUE READING
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