Host adaptive immunity alters gut microbiota

  title={Host adaptive immunity alters gut microbiota},
  author={Husen Zhang and Joshua B Sparks and Saikumar V Karyala and Robert Settlage and Xin M Luo},
  journal={The ISME Journal},
It has long been recognized that the mammalian gut microbiota has a role in the development and activation of the host immune system. Much less is known on how host immunity regulates the gut microbiota. Here we investigated the role of adaptive immunity on the mouse distal gut microbial composition by sequencing 16 S rRNA genes from microbiota of immunodeficient Rag1−/− mice, versus wild-type mice, under the same housing environment. To detect possible interactions among immunological status… CONTINUE READING
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