Host Transcript Accumulation during Lytic KSHV Infection Reveals Several Classes of Host Responses

@article{Chandriani2007HostTA,
  title={Host Transcript Accumulation during Lytic KSHV Infection Reveals Several Classes of Host Responses},
  author={Sanjay J. Chandriani and Donald E Ganem},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={1186 - 1191}
}
Lytic infection by Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with an extensive shutoff of host gene expression, mediated chiefly by accelerated mRNA turnover due to expression of the viral SOX protein. We have previously identified a small number of host mRNAs that can escape SOX-mediated degradation. Here we present a detailed, transcriptome-wide analysis of host shutoff, with careful microarray normalization to allow rigorous determination of the magnitude and extent of… CONTINUE READING
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