Host Response and Dysfunction in the CNS during Chronic Simian Immunodeficiency Virus Infection

  title={Host Response and Dysfunction in the CNS during Chronic Simian Immunodeficiency Virus Infection},
  author={E. Roberts and S. Huitr{\'o}n-Res{\'e}ndiz and M. Taffe and M. Marcondes and C. Flynn and C. Lanigan and J. A. Hammond and S. Head and S. Henriksen and H. Fox},
  journal={The Journal of Neuroscience},
  pages={4577 - 4585}
  • E. Roberts, S. Huitrón-Reséndiz, +7 authors H. Fox
  • Published 2006
  • Biology, Medicine
  • The Journal of Neuroscience
  • CNS abnormalities can be detected during chronic human immunodeficiency virus (HIV) infection, before the development of opportunistic infections or other sequelae of immunodeficiency. However, although end-stage dementia caused by HIV has been linked to the presence of infected and activated macrophages and microglia in the brain, the nature of the changes resulting in the motor and cognitive disorders in the chronic stage is unknown. Using simian immunodeficiency virus-infected rhesus monkeys… CONTINUE READING
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