Host Range Restriction and Pathogenicity in the Context of Influenza Pandemic

@inproceedings{Neumann2006HostRR,
  title={Host Range Restriction and Pathogenicity in the Context of Influenza Pandemic},
  author={Gabriele Neumann and Yoshihiro Kawaoka},
  booktitle={Emerging infectious diseases},
  year={2006}
}
Influenza A viruses cause pandemics at random intervals. Pandemics are caused by viruses that contain a hemagglutinin (HA) surface glycoprotein to which human populations are immunologically naive. Such an HA can be introduced into the human population through reassortment between human and avian virus strains or through the direct transfer of an avian influenza virus to humans. The factors that determine the interspecies transmission and pathogenicity of influenza viruses are still poorly… CONTINUE READING

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