Host-Pathogen Coupled Networks: Model for Bacillus Anthracis Interaction with Host Macrophages

@inproceedings{Robinson2015HostPathogenCN,
  title={Host-Pathogen Coupled Networks: Model for Bacillus Anthracis Interaction with Host Macrophages},
  author={Peter J. Robinson and Cornelis Erik Hack and Amanda L. Hanes and Emily J. Fleming and Jeffery Gearhart and Kyung Ok Yu},
  year={2015}
}
Abstract : Macrophages are key in establishing Bacillus anthracis (BA) infection via spore germination, and providing transportation to the regional lymph nodes where vegetative BA bacteria synthesize protective antigen (PA), lethal factor (LF), and edema factor (EF) for release into circulation. PA binds to anthrax toxin receptors on the endosomal membrane to form oligomeric pores that mediate transport of LF (and EF) into the cytosol, where it accumulates, causing macrophage death and the… CONTINUE READING

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