Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence.

@article{Urbano2018HostNO,
  title={Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence.},
  author={Rodolfo Urbano and Joyce E. Karlinsey and Stephen J. Libby and P T Doulias and Harry Ischiropoulos and Helen I Warheit-Niemi and Denny H. Liggitt and Alexander R. Horswill and Ferric C Fang},
  journal={Cell host & microbe},
  year={2018},
  volume={23 5},
  pages={594-606.e7}
}
Staphylococcus aureus is a commensal bacterium that can asymptomatically colonize its host but also causes invasive infections. Quorum sensing regulates S. aureus virulence and the transition from a commensal to a pathogenic organism. However, little is known about how host innate immunity affects interbacterial communication. We show that nitric oxide… CONTINUE READING