Host Factors in Retroviral Integration and the Selection of Integration Target Sites.

@article{Craigie2014HostFI,
  title={Host Factors in Retroviral Integration and the Selection of Integration Target Sites.},
  author={Robert Craigie and Frederic D. Bushman},
  journal={Microbiology spectrum},
  year={2014},
  volume={2 6}
}
In order to replicate, a retrovirus must integrate a DNA copy of the viral RNA genome into a chromosome of the host cell. The study of retroviral integration has advanced considerably in the past few years. Here we focus on host factor interactions and the linked area of integration targeting. Genome-wide screens for cellular factors affecting HIV replication have identified a series of host cell proteins that may mediate subcellular trafficking for preintegration complexes, nuclear import, and… CONTINUE READING

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