Host Defense and Tolerance: Unique Challenges in the Placenta

Abstract

Mammalian gestation creates an immunological paradox wherein the body must balance tolerance of an allogeneic fetus with protection against invading pathogens. Pregnancy has long been considered a state of immune suppression that, while necessary for reproduction, increases a woman’s susceptibility to infection [1]. However, mothers bear the responsibility… (More)
DOI: 10.1371/journal.ppat.1002804

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