Host Defense Functions of Pulmonary Surfactant
@article{Wright2004HostDF, title={Host Defense Functions of Pulmonary Surfactant}, author={J. Wright}, journal={Neonatology}, year={2004}, volume={85}, pages={326 - 332} }
Surfactant is a complex of lipids and proteins that reduces surface tension at the air/liquid interface of the lung and regulates immune cell function. Surfactant immune function is primarily attributed to two proteins: SP-A and SP-D. SP-A and SP-D are members of a protein family known as ‘collectins’, which are distinguished by their N-terminal collagen-like region and their C-terminal lectin domain. The lectin domain binds preferentially to sugars on the surface of pathogens and thereby… CONTINUE READING
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