Host Defense Functions of Pulmonary Surfactant

  title={Host Defense Functions of Pulmonary Surfactant},
  author={J. Wright},
  pages={326 - 332}
  • J. Wright
  • Published 2004
  • Biology, Medicine
  • Neonatology
  • Surfactant is a complex of lipids and proteins that reduces surface tension at the air/liquid interface of the lung and regulates immune cell function. Surfactant immune function is primarily attributed to two proteins: SP-A and SP-D. SP-A and SP-D are members of a protein family known as ‘collectins’, which are distinguished by their N-terminal collagen-like region and their C-terminal lectin domain. The lectin domain binds preferentially to sugars on the surface of pathogens and thereby… CONTINUE READING
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    • 7
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    • 17
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    Immunomodulatory functions of surfactant.
    • 354
    Collectins and pulmonary host defense.
    • E. Crouch
    • Biology, Medicine
    • American journal of respiratory cell and molecular biology
    • 1998
    • 384
    • PDF
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    • 604
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    • 241
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    • 234
    • PDF
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