Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice.

@article{Wu2011HostDR,
  title={Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice.},
  author={Min Wu and Huang Huang and Weidong Zhang and Shibichakravarthy Kannan and Andrew Brian Weaver and Molynda McKibben and Danielle Herington and Huawei Zeng and Hongwei Gao},
  journal={Infection and immunity},
  year={2011},
  volume={79 1},
  pages={
          75-87
        }
}
Although DNA repair proteins in bacteria are critical for pathogens' genome stability and for subverting the host defense, the role of host DNA repair proteins in response to bacterial infection is poorly defined. Here, we demonstrate, for the first time, that infection with the Gram-negative bacterium Pseudomonas aeruginosa significantly altered the expression and enzymatic activity of 8-oxoguanine DNA glycosylase (OGG1) in lung epithelial cells. Downregulation of OGG1 by a small interfering… CONTINUE READING

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