Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.

@article{McKee2013HostDR,
  title={Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.},
  author={Amy S McKee and Matthew A. Burchill and Michael W Munks and Lei Jin and John W Kappler and Rachel S. Friedman and Jordan Jacobelli and Philippa Marrack},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 12},
  pages={
          E1122-31
        }
}
  • Amy S McKee, Matthew A. Burchill, +5 authors Philippa Marrack
  • Published in
    Proceedings of the National…
    2013
  • Biology, Medicine
  • Many vaccines include aluminum salts (alum) as adjuvants despite little knowledge of alum's functions. Host DNA rapidly coats injected alum. Here, we further investigated the mechanism of alum and DNA's adjuvant function. Our data show that DNase coinjection reduces CD4 T-cell priming by i.m. injected antigen + alum. This effect is partially replicated in mice lacking stimulator of IFN genes, a mediator of cellular responses to cytoplasmic DNA. Others have shown that DNase treatment impairs… CONTINUE READING

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