Host Cell Transcriptome Profile during Wild-Type and Attenuated Dengue Virus Infection

@inproceedings{Sessions2013HostCT,
  title={Host Cell Transcriptome Profile during Wild-Type and Attenuated Dengue Virus Infection},
  author={October Michael Sessions and Ying Tan and Kenneth Choon Meng Goh and Yujing Liu and Patrick Tan and Steve Rozen and Eng Eong Ooi},
  booktitle={PLoS neglected tropical diseases},
  year={2013}
}
Dengue viruses 1-4 (DENV1-4) rely heavily on the host cell machinery to complete their life cycle, while at the same time evade the host response that could restrict their replication efficiency. These requirements may account for much of the broad gene-level changes to the host transcriptome upon DENV infection. However, host gene function is also regulated through transcriptional start site (TSS) selection and post-transcriptional modification to the RNA that give rise to multiple gene… CONTINUE READING
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