Host Cell Factors as Antiviral Targets in Arenavirus Infection

  title={Host Cell Factors as Antiviral Targets in Arenavirus Infection},
  author={Florencia N. Linero and Claudia Soledad Sep{\'u}lveda and Federico Giovannoni and Viviana Castilla and Cybele C. Garc{\'i}a and Luis Alberto Scolaro and Elsa B Damonte},
Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. Since diverse host cell pathways and enzymes are used by RNA viruses to fulfill their replicative cycle… CONTINUE READING
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