Host-Bacterial Mutualism in the Human Intestine

@article{Bckhed2005HostBacterialMI,
  title={Host-Bacterial Mutualism in the Human Intestine},
  author={Fredrik B{\"a}ckhed and Ruth E. Ley and Justin Laine Sonnenburg and Daniel A Peterson and Jeffrey I. Gordon},
  journal={Science},
  year={2005},
  volume={307},
  pages={1915 - 1920}
}
The distal human intestine represents an anaerobic bioreactor programmed with an enormous population of bacteria, dominated by relatively few divisions that are highly diverse at the strain/subspecies level. This microbiota and its collective genomes (microbiome) provide us with genetic and metabolic attributes we have not been required to evolve on our own, including the ability to harvest otherwise inaccessible nutrients. New studies are revealing how the gut microbiota has coevolved with us… 

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References

SHOWING 1-10 OF 38 REFERENCES

Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont

It is found that Bacteroides thetaiotaomicron bacteria assembled on food particles and mucus, selectively induced outer-membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of liberated hexose sugars, and revealed a capacity to turn to host mucus glycans whenpolysaccharides were absent from the diet.

Getting a grip on things: how do communities of bacterial symbionts become established in our intestine?

It is proposed that the mucus gel layer overlying the intestinal epithelium is a key contributor to the structural and functional stability of this microbiota and its tolerance by the host.

Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation.

At the mucosal surface, where microbes encounter continuous attack by host defenses, BF evasion of the immune system is favored, and its colonization and infectious potential are increased.

The Host Genotype Affects the Bacterial Community in the Human Gastrointestinal Tract

The data indicate that factors related to the host genotype have an important effect on determining the bacterial composition in the GI tract.

Microbial ecology of the gastrointestinal tract.

  • D. Savage
  • Medicine, Environmental Science
    Annual review of microbiology
  • 1977
A comparison study of how microbes in the BIOTA make their living (NICHES) and the localization of climax communities in adults reveals a complex web of interactions between the host organism and the environment.

Metabolic interactions between anaerobic bacteria in methanogenic environments

  • A. Stams
  • Biology
    Antonie van Leeuwenhoek
  • 2004
Syntrophic relationships which depend on interspecies hydrogen or formate transfer were described for the degradation of e.g. fatty acids, amino acids and aromatic compounds in methanogenic environments.

The gut microbiota as an environmental factor that regulates fat storage.

It is found that conventionalization of adult germ-free (GF) C57BL/6 mice with a normal microbiota harvested from the distal intestine of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.

Influence of intestinal microbes on heat production in germ-free, gnotobiotic and conventional mice.

To observe the influence of intestinal microbes on energy metabolism, male ICR strain germ-free (GF) mice, gnotobiotic (GB) mice, produced from GF mice monocontaminated with Staphylococcus

Human fecal flora: the normal flora of 20 Japanese-Hawaiians.

Quantitative and qualitative examination of the fecal flora of 20 clinically healthy Japanese-Hawaiian males was carried out by using anaerobic tube culture techniques, and differential characteristics of previously unreported species are presented.

Impact of Culture-Independent Studies on the Emerging Phylogenetic View of Bacterial Diversity

Our perspective on microbial diversity has improved enormously over the past few decades. In large part this has been due to molecular phylogenetic studies that objectively relate organisms.