Host–guest encapsulation of materials by assembled virus protein cages

@article{Douglas1998HostguestEO,
  title={Host–guest encapsulation of materials by assembled virus protein cages},
  author={T. Douglas and M. Young},
  journal={Nature},
  year={1998},
  volume={393},
  pages={152-155}
}
  • T. Douglas, M. Young
  • Published 1998
  • Chemistry
  • Nature
    • Self-assembled cage structures of nanometre dimensions can be used as constrained environments for the preparation of nanostructured materials, and the encapsulation of guest molecules, with potential applications in drug delivery and catalysis. In synthetic systems the number of subunits contributing to cage structures is typically rather small,. But the protein coats of viruses (virions) commonly comprise hundreds of subunits that self-assemble into a cage for transporting viral nucleic acids… CONTINUE READING
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    References

    SHOWING 1-10 OF 45 REFERENCES
    Synthesis of inorganic nanophase materials in supramolecular protein cages
    • 351
    A chiral spherical molecular assembly held together by 60 hydrogen bonds
    • 754
    Acceleration of a Diels–Alder reaction by a self-assembled molecular capsule
    • 351
    Preparation and Characterization of Au Colloid Monolayers
    • 2,126
    Quasi-equivalent viruses: a paradigm for protein assemblies.
    • 259
    Quantum Confinement and Host/Guest Chemistry: Probing a New Dimension
    • 472
    Structures of the native and swollen forms of cowpea chlorotic mottle virus determined by X-ray crystallography and cryo-electron microscopy.
    • 576
    • PDF
    Synthesis and Application of Modulated Polymer Gels
    • 403
    Solution conformation of a peptide fragment representing a proposed RNA-binding site of a viral coat protein studied by two-dimensional NMR.
    • 17
    Three-dimensional structure of poliovirus at 2.9 A resolution.
    • 1,079