• DOI:10.1056/NEJMoa1306742
• Corpus ID: 211221

Hospital outbreak of Middle East respiratory syndrome coronavirus.

@article{Assiri2013HospitalOO,
  title={Hospital outbreak of Middle East respiratory syndrome coronavirus.},
  author={Abdullah M Assiri and Allison J. McGeer and Trish M. Perl and Connie Savor Price and Abdullah A. Al Rabeeah and Derek A. T. Cummings and Zaki N Alabdullatif and Maher Assad and Abdulmohsen Almulhim and Hatem Q. Makhdoom and Hossam Madani and Rafat F. Alhakeem and Jaffar A. Al-Tawfiq and Matthew Cotten and Simon J. Watson and Paul Kellam and Alimuddin Zumla and Ziad A. Memish},
  journal={The New England journal of medicine},
  year={2013},
  volume={369 5},
  pages={
          407-16
        }
}

• A. Assiri, A. McGeer, +15 authors Z. Memish
• Published 31 July 2013
• Medicine
• The New England journal of medicine

BACKGROUND
In September 2012, the World Health Organization reported the first cases of pneumonia caused by the novel Middle East respiratory syndrome coronavirus (MERS-CoV). We describe a cluster of health care-acquired MERS-CoV infections.

METHODS
Medical records were reviewed for clinical and demographic information and determination of potential contacts and exposures. Case patients and contacts were interviewed. The incubation period and serial interval (the time between the successive onset of symptoms in a chain of transmission) were estimated. Viral RNA was sequenced.

RESULTS
Between April 1 and May 23, 2013, a total of 23 cases of MERS-CoV infection were reported in the eastern province of Saudi Arabia. Symptoms included fever in 20 patients (87%), cough in 20 (87%), shortness of breath in 11 (48%), and gastrointestinal symptoms in 8 (35%); 20 patients (87%) presented with abnormal chest radiographs. As of June 12, a total of 15 patients (65%) had died, 6 (26%) had recovered, and 2 (9%) remained hospitalized. The median incubation period was 5.2 days (95% confidence interval [CI], 1.9 to 14.7), and the serial interval was 7.6 days (95% CI, 2.5 to 23.1). A total of 21 of the 23 cases were acquired by person-to-person transmission in hemodialysis units, intensive care units, or in-patient units in three different health care facilities. Sequencing data from four isolates revealed a single monophyletic clade. Among 217 household contacts and more than 200 health care worker contacts whom we identified, MERS-CoV infection developed in 5 family members (3 with laboratory-confirmed cases) and in 2 health care workers (both with laboratory-confirmed cases).

CONCLUSIONS
Person-to-person transmission of MERS-CoV can occur in health care settings and may be associated with considerable morbidity. Surveillance and infection-control measures are critical to a global public health response.