Horseradish peroxidase catalyzed nitric oxide formation from hydroxyurea.

@article{Huang2002HorseradishPC,
  title={Horseradish peroxidase catalyzed nitric oxide formation from hydroxyurea.},
  author={Jinming Huang and Erin M Sommers and Daniel B. Kim-Shapiro and S Bruce King},
  journal={Journal of the American Chemical Society},
  year={2002},
  volume={124 13},
  pages={3473-80}
}
Hydroxyurea represents an approved treatment for sickle cell anemia and a number of cancers. Chemiluminescence and electron paramagnetic resonance spectroscopic studies show horseradish peroxidase catalyzes the formation of nitric oxide from hydroxyurea in the presence of hydrogen peroxide. Gas chromatographic headspace analysis and infrared spectroscopy also reveal the production of nitrous oxide in this reaction, which provides evidence for nitroxyl, the one-electron reduced form of nitric… CONTINUE READING
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