Hormones, growth factors, and myogenic differentiation.

  title={Hormones, growth factors, and myogenic differentiation.},
  author={James R. Florini and Daina Z. Ewton and K A Magri},
  journal={Annual review of physiology},
Three families of growth factors/hormones have major effects on the differentiation of skeletal muscle cells. Two (FGF and TGF-beta) are potent inhibitors, and the third (IGF) exhibits a biphasic stimulatory action (but is not inhibitory even at high concentrations). All of these affect the expression of myogenin, one of the recently discovered family of myogenesis controlling genes, and FGF and TGF-beta have been shown to inhibit the expression of MyoD1 (and probably myf-5 and herculin) as… CONTINUE READING
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