Hormonelle Antiandrogene in der Aknetherapie

@article{Zouboulis2010HormonelleAI,
  title={Hormonelle Antiandrogene in der Aknetherapie},
  author={Christos C. Zouboulis and Th. Rabe},
  journal={JDDG: Journal der Deutschen Dermatologischen Gesellschaft},
  year={2010},
  volume={8}
}
  • C. Zouboulis, T. Rabe
  • Published 1 March 2010
  • Medicine
  • JDDG: Journal der Deutschen Dermatologischen Gesellschaft
BACKGROUND: An enhanced sebaceous gland activity with production of proinflammtory sebaceous lipids belongs to the major pathogenetic factors of acne. Hormonal antiandrogen treatment targets the androgen-metabolizing cells of the pilosebaceous unit, i. e. follicular kertinocytes and sebocytes, and leads to sebostasis, with a reduction of the sebum secretion rate of 12.5 to 65 %. Concerning their mechanism of action, hormonal antiandrogens are classified in androgen receptor blockers, inhibitors… Expand
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