Hormone therapy increases risk of ulcerative colitis but not Crohn's disease.

BACKGROUND & AIMS Estrogen has been proposed to modulate gut inflammation through an effect on estrogen receptors found on gastrointestinal epithelial and immune cells. The role of postmenopausal hormone therapy on risk of Crohn's disease (CD) and ulcerative colitis (UC) is unclear. METHODS We conducted a prospective cohort study of 108,844 postmenopausal… CONTINUE READING