Hormone therapy and mood in perimenopausal and postmenopausal women: a narrative review

@article{Toffol2015HormoneTA,
  title={Hormone therapy and mood in perimenopausal and postmenopausal women: a narrative review},
  author={Elena Toffol and Oskari Heikinheimo and Timo Partonen},
  journal={Menopause},
  year={2015},
  volume={22},
  pages={564–578}
}
ObjectiveBetween 15% and 50% of women experience depressive symptoms during the menopausal transition; in 15% to 30% of perimenopausal women, they are severe enough to be regarded as a depressive disorder. Fluctuations in gonadal hormone levels are thought to contribute to these depressive conditions. Hormone therapy is commonly used to alleviate climacteric symptoms, but its effects on mood are less clear. We narratively reviewed the literature on the effects of different types of hormone… 

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Because the most dramatic hormonal changes associated with menopause are related to estrogen and because estrogen is usually coadministered with a progestogen in patients with an intact uterus, this review is focused primarily on ERT/HRT.
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