Hormone therapy and mood in perimenopausal and postmenopausal women: a narrative review

@article{Toffol2015HormoneTA,
  title={Hormone therapy and mood in perimenopausal and postmenopausal women: a narrative review},
  author={Elena Toffol and Oskari Heikinheimo and Timo Partonen},
  journal={Menopause},
  year={2015},
  volume={22},
  pages={564–578}
}
ObjectiveBetween 15% and 50% of women experience depressive symptoms during the menopausal transition; in 15% to 30% of perimenopausal women, they are severe enough to be regarded as a depressive disorder. Fluctuations in gonadal hormone levels are thought to contribute to these depressive conditions. Hormone therapy is commonly used to alleviate climacteric symptoms, but its effects on mood are less clear. We narratively reviewed the literature on the effects of different types of hormone… 
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References

SHOWING 1-10 OF 85 REFERENCES

Effect of estrogen replacement therapy on symptoms of depression and anxiety in non-depressive menopausal women

Erosion replacement therapy is not associated with improvements in mood or anxiety symptoms in non-depressive, hysterectomized, postmenopausal women.

Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal women.

This small study suggests that for some antidepressant-naive perimenopausal women with clinical depression, ERT may have antidepressant efficacy in depressed women who have minimal response to a selective serotonin reuptake inhibitor.

Depression and the menopause: why antidepressants are not enough?

The combination of the antidepressant with HT seems to offer the best therapeutic potential in terms of efficacy, rapidity of improvement and consistency of remission in the follow-up, as well as the synergistic effect between HT and antidepressants in treating menopausal depression.

Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial.

Transdermal estradiol replacement is an effective treatment of depression for perimenopausal women and sustained antidepressant benefit of treatment after the 4-week washout period, although somatic complaints increased in frequency and intensity.

Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary report.

Some perimenopausal women with depression may benefit from short-term use of estrogen therapy, and its role for postmenopausal depressed women warrants further investigation.

Associations of hormones and menopausal status with depressed mood in women with no history of depression.

Transition to menopause and its changing hormonal milieu are strongly associated with new onset of depressed mood among women with no history of depression.

Efficacy of citalopram as a monotherapy or as an adjunctive treatment to estrogen therapy for perimenopausal and postmenopausal women with depression and vasomotor symptoms.

Citalopram alone is an efficacious treatment for perimenopausal and postmenopausal women with depression and appears to be efficacious as an adjunctive treatment for depressed subjects who remain symptomatic after treatment with E(2) (i.e., E( 2) nonremitters).

Estrogen augmentation of antidepressants in perimenopausal depression: a pilot study.

Short-term, low-dose estrogen augmentation of antidepressant medication was significantly associated with improved mood, but not memory, in perimenopausal women with MDD in partial remission.

Challenges and opportunities to manage depression during the menopausal transition and beyond.

Quality of life and menopause: the role of estrogen.

  • M. Freedman
  • Medicine, Biology
    Journal of women's health
  • 2002
Because the most dramatic hormonal changes associated with menopause are related to estrogen and because estrogen is usually coadministered with a progestogen in patients with an intact uterus, this review is focused primarily on ERT/HRT.
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