Hormone therapy, DNA methylation and colon cancer.

  title={Hormone therapy, DNA methylation and colon cancer.},
  author={Anna H Wu and Kimberly D. Siegmund and Tiffany I. Long and Wendy Cozen and Peggy C Wan and Chiu-chen Tseng and Darryl Shibata and Peter W. Laird},
  volume={31 6},
Observational epidemiological studies and randomized trials have reported a protective effect of estrogen and progestin therapy (EPT) on the risk of colorectal cancer but the findings on estrogen-alone therapy (ET) are less consistent. The mechanism by which menopausal hormones influence risk of colorectal cancer has not been well studied. To further investigate the relationship between menopausal hormones and risk of colon cancer, we conducted a population-based case-control study in Los… CONTINUE READING