Hormone synthesis in human thyroglobulin: Possible cleavage of the polypeptide chain at the tyrosine donor site

@article{Marriq1989HormoneSI,
  title={Hormone synthesis in human thyroglobulin: Possible cleavage of the polypeptide chain at the tyrosine donor site},
  author={C Marriq and Pierre Jean Lejeune and Nicole Venot and Liliane Vinet},
  journal={FEBS Letters},
  year={1989},
  volume={242}
}
Tyrosine 130 Is an Important Outer Ring Donor for Thyroxine Formation in Thyroglobulin*
TLDR
It is concluded that Tyr130 is an important donor of the outer iodothyronine ring, because Tyr5 and Tyr130 are proximate, because they are the most prominent early iodination sites in this part of thyroglobulin, and because the N-terminal region was previously found capable of forming T4 by itself.
Iodine induced alteration in immunological and biochemical properties of thyroglobulin.
TLDR
The iodine-iodide induced inactivation of hTg autoepitopes is pH dependent and is possibly caused by iodination of tyrosyl residues present in the epitope structure.
Revisiting Iodination Sites in Thyroglobulin with an Organ-oriented Shotgun Strategy
TLDR
This work shows that semi-quantitation of Tg iodination states is feasible for human biopsies and should be of significant medical interest for further characterization of human thyroid pathologies.
TSH-induced galactose incorporation at the NH2 terminus of thyroglobulin secreted by FRTL-5 cells.
Defective thyroglobulin synthesis and secretion causing goiter and hypothyroidism
TLDR
In this review, the abnormalities in the synthesis of Tg described in both animals and man are reviewed to cover and the molecular basis of these defects have been recently reported in a patient.
A second thyroglobulin messenger RNA species (rTg-2) in rat thyrocytes.
TLDR
This smaller transcript has not previously been reported and encodes elements known to be of structural and functional significance in the 330-kD Tg monomer and may play an important role in thyroid function and thyroid autoimmunity.
The influence of iodine on the immunological properties of thyroglobulin and its immunological complexes.
TLDR
Thyroglobulin preincubation with iodine solutions decreased aAbs binding from all tested sera of patients with autoimmune thyroid disease (AITD) and a product of iodine disproportionation reaction induces changes in the Tg molecule and Tg-aAb's complexes leading to complex dissociation or epitope inactivation.
...
...

References

SHOWING 1-10 OF 16 REFERENCES
Polypeptide chains of 19-S thyroglobulin from several mammalian species and of porcine 27-S iodoprotein.
TLDR
Identity, both qualitatively and quantitatively, of the peptides obtained by CNBr cleavage of the two proteins as shown by sodium dodecylsulfate/polyacrylamide gel electrophoresis has confirmed the idea that the protein is formed of two identical chains.
Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA.
TLDR
The mRNA encoding human thyroglobulin has been cloned and sequenced and shows an interesting homology with the acetylcholinesterase of Torpedo californica.
...
...