Hormone-sensitive lipase deficiency disturbs the fatty acid composition of mouse testis.

  title={Hormone-sensitive lipase deficiency disturbs the fatty acid composition of mouse testis.},
  author={Mar{\'i}a Emilia Casado and Oscar Meruvia Pastor and Paloma Mariscal and Alberto Canfr{\'a}n-Duque and Javier Mart{\'i}nez-Botas and Fredric B Kraemer and Miguel Angel Lasunci{\'o}n and Antonia Mart{\'i}n-Hidalgo and Rebeca Busto},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  volume={88 3},
Hormone-sensitive lipase (HSL) is a key enzyme in the mobilization of fatty acids from intracellular stores. In mice, HSL deficiency results in male sterility caused by a major defect in spermatogenesis. The testes contain high concentrations of PUFA and specific PUFA are essential for spermatogenesis. We investigated the fatty acid composition and the mRNA levels of key enzymes involved in fatty acid metabolism in testis of HSL-knockout mice. HSL deficiency altered fatty acid composition in… CONTINUE READING
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Identification of a lipokine , a lipid hormone linking adipose tissue to systemic metabolism

  • K. Gerhold H. Cao, J. R. Mayers, M. M. Wiest, S. M. Watkins, G. S. Hotamisligil
  • PLoS One
  • 2011

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