Hormone response of rodent phenylalanine hydroxylase requires HNF1 and the glucocorticoid receptor.

@article{Bristeau2001HormoneRO,
  title={Hormone response of rodent phenylalanine hydroxylase requires HNF1 and the glucocorticoid receptor.},
  author={A Bristeau and A M Catherin and Mary C. Weiss and Daniela M. Faust},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={287 4},
  pages={852-8}
}
Expression of the rodent phenylalanine hydroxylase (PAH) gene is dependent upon hormones. Induction by glucocorticoids and cAMP occurs slowly and maximal stimulation is obtained by a synergistic effect of the two compounds. Hormone responsiveness is conferred by the tissue-specific HSIII enhancer and involves (i) protein kinase A mediating the cAMP response, even though a consensus sequence for binding of the cAMP response element binding protein is not present; (ii) other serine/threonine… CONTINUE READING

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