Hormone replacement therapy and the association with coronary heart disease and overall mortality: Clinical application of the timing hypothesis

@article{Hodis2014HormoneRT,
  title={Hormone replacement therapy and the association with coronary heart disease and overall mortality: Clinical application of the timing hypothesis},
  author={Howard N. Hodis and Wendy Jean Mack},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2014},
  volume={142},
  pages={68-75}
}
  • H. Hodis, W. Mack
  • Published 1 July 2014
  • Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
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TLDR
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TLDR
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Timing of Estradiol Treatment After Menopause May Determine Benefit or Harm to Insulin Action.
TLDR
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Cardiovascular and sexual health effects of postmenopausal testosterone therapy
TLDR
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Cumulated data support a ‘window-of-opportunity’ for maximal reduction of CHD and overall mortality and minimization of risks with HRT initiation before 60 years of age and/or within 10 years of menopause and continued for 6 years or more.
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Whether the effects of hormone therapy on risk of cardiovascular disease vary by age or years since menopause began is explored to explore and women who initiated hormone therapy closer toMenopause tended to have reduced CHD risk compared with the increase inCHD risk among women more distant from menopausal symptoms.
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Hormone therapy is associated with an increased risk of stroke, and this increased risk does not appear to be related to the timing of the initiation of HT, in younger women, with lower stroke risk.
Brief report: Coronary heart disease events associated with hormone therapy in younger and older women
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TLDR
The association between postmenopausal estrogen use and all-cause, coronary heart disease, stroke, all-cancer, and breast cancer death rates and whether these associations differed by body mass was examined in 290,827 post menopausal US women.
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